The hottest way to package single dose drugs

2022-08-22
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Talking about the method of packaging single dose drugs

for more than 40 years after the emergence of rigid foam plastic liner packaging, it has improved a cost-effective and applicable packaging method for the packaging of unit dose drugs. It has been proved that the rigid foamed plastic liner packaging material is a kind of packaging material that is durable, useful and suitable for a wide range of applications. Therefore, in the European market, even if the changes in the institutional environment are not conducive to the sales of rigid foamed plastic cushion packaging materials, its popular trend has not weakened at all

as a product that appeared in the 1960s, rigid foamed plastic liner packaging material was initially used as an auxiliary for patient orthotics. When the oral contraceptive came into the market, the rigid foam packing material became more and more important. At that time, there were several other packaging materials on the market, such as packaging boxes, metal and glass tubes, bottles and composite films, but none of them could be widely used as rigid foam liner packaging materials. In addition to improving the comfort of patients' orthotics, the rigid foamed plastic liner packaging material is easy to use and mold, and can also protect the product and ensure the stability of the product. Hygroscopic tablets that are easy to absorb water from the surrounding environment, or fragile tablets that are very easy to break, are very suitable for external packaging with this material

after being selected as the packaging material for oral contraceptives, the advantages and wide applications of rigid foam liner packaging materials immediately showed up Then choose one of the expensive experimental equipment. Compared with the bottled tablets, the packaging cost and storage cost of the products are reduced, which benefits the manufacturers. Moreover, more contents, including patient information and trademark information, can be printed on the rigid foamed plastic liner packaging material

a manufacturer of rigid foamed plastic packing machine in Germany first developed a method to meet this demand; Subsequently, Italian manufacturers also worked out countermeasures So far, Wu is the main production country of rigid foamed plastic liner packaging machine

manufacturers developed basic operating principles for packaging machines produced in the early stage, some of which are still applied today. For example, the earliest packaging machines used intermittent motion rules for molding, sealing, punching, cutting and other operations. Until today, many packaging machines still use these technologies But the basic operating principle has changed a lot. Compared with its ancestors, the latest packaging machine has been highly evolved. In recent years, the rigid foam plastic liner packaging machine has been integrated into the complete packaging production line, and the output has also been greatly increased. Moreover, its application scope has also been expanded, and it can pack a variety of products. The corresponding types of rigid foamed plastic liner packaging machines can be bought in the market. The first combination of rigid foam liner packaging machine and paperboard packaging machine was in the mid-1960s. Ten years later, the first fully integrated compact production line appeared These early solutions are the ancestors of the computer-managed packaging machines now in use. Now, high-tech systems enable full automation from the filling and palletization of products

in Europe, the 1980s was a period of rapid growth of rigid foam liner packaging materials, because governments across the European continent began to advocate organic materials as the preferred way of drug packaging. The main advantage of packaging with organic packaging materials is that it can largely eliminate the problems of drug pollution, distribution errors and so on. In this way, when drugs are distributed to patients, it is the same as when they first leave the packaging production line

this is completely different from the traditional dispensing method. In the traditional dispensing method, pharmacists distribute drugs from the drugs supplied in bulk according to the amount of drugs required by patients

in response to this market trend, packaging machine manufacturers began to increase production. In the early 1980s, the production of 420 rigid foamed plastic liner packaging materials per minute was very fast. At the end of the 1980s, the production rate doubled, and today, the output has reached 1200 per minute

another impact of packaging with organic packaging materials is that drug manufacturers have increased their negative impact on the safety of drugs and packaging. Eliminating pharmacy dispensing reduces the risk of drug dispensing errors, but it also removes the last line of control before drugs reach patients. The method of visual inspection by operators once became a solution. However, with the increasing production speed of products, the efficiency of this method of visual inspection became lower and lower, so cameras and sensors were introduced for complete electronic supervision. At this time, the packaging machine is required to be well compatible with these electronic supervision equipment

there are many kinds of materials used for rigid foam liner packaging. The original rigid foam liner packaging was made by Jie; It is made of polyethylene chloride (PVC) and sealed with aluminum film So far, some products are packaged with this composite film. For example, some candies containing pharmaceutical ingredients, but generally, drugs with drug licenses are packaged with other composite films

there are two main factors that promote the change of packaging materials. First, new packaging materials that can better protect drugs have appeared in the market. Second, the pressure of laws and regulations adjustment will also have a great impact on manufacturers. The importance of drug protection has a lot to do with the sensitivity of notebook connectors to humidity and the climatic conditions of the region where the products are supplied. Because PVC has permeability after long storage, it is not suitable for packaging sensitive drugs in humid areas. For many years, people have been studying its alternative products. Including polyvinyl chloride (PVO) and polyethylene oxide (PVDC) composite films, multilayer special films, polyethylene terephthalate (PET), polypropylene (PP), and recently developed cold formed aluminum films or aluminum aluminum composite films. Among them, gundo composite membrane is still in use. Some composite membranes require special molding environments. For example, polypropylene (PP) has special properties during heating, so it needs special treatment. When pressing aluminum film, we must pay attention to avoid the stress points of aluminum, otherwise small holes will appear on the aluminum film

the adjustment of national policies and regulations has a great impact on the selection of packaging methods and packaging materials. In 1970, the United States enacted the prevention of packaging poisoning act, which led to the development of child safety rigid foam liner packaging. In this way, great changes have taken place in the packaging of rigid foamed plastic liners, and there are some particularly complex packaging that are difficult to produce and open. As a result, only 20% of drug manufacturers in the United States still use rigid foam liner packaging, and the vast majority of them are oral contraceptive tablet manufacturers, because few children are poisoned by oral contraceptive tablets

in 1979, the German Standards Association formulated the DIN standard for drug packaging, which introduced a more user-friendly solution. D? The standard is based on the change of packaging cover materials and the change of l-piercing technology. Specifications for push and pull rigid foam liner packaging have emerged. These specifications meet the requirements of policies and regulations. Compared with similar specifications in the United States, they adopt fewer extreme measures, which is very reasonable. Due to the relevant regulations of the UK over the counter drug regulatory commission (pagb) and the over the counter drug manufacturers' chamber of Commerce, although in recent years, rigid foam padded packaging and strip packaging have been used more and more. However, the risk of poisoning by accidental ingestion of drugs has not increased

many European countries are considering legislation on rigid foamed plastic liner packaging. Europe will soon establish its own norms. At that time, in all European Member States, the new laws will replace the existing laws to play a role. At the same time, drug manufacturers must try to find a compromise solution, so that the drugs designed in the new law can not only ensure the safety of children, but also do not violate the principle of convenient use for adults, and this compromise solution should have a minimum impact on the production process and production cost of drugs

in all business fields, cost department is the core factor The average life expectancy of most countries in the world is increasing: This is a very good situation, but it also makes the budget of health care inevitably tight. As a result, the government put pressure on drug manufacturers to reduce drug prices with the corresponding latest detailed introductions on product technology, performance and use. This debate has continued to this day, and in the past decade, there have been some changes in the way pharmaceutical companies operate. The new business model has a great impact on the role of rigid foamed plastic liner packaging machine, and also disintegrated the dividing line of traditional packaging machine production industry

the biggest change occurs in the level of resource utilization. Traditionally, the utilization level of equipment in the pharmaceutical sector is much lower than that in other industrial sectors, because outsourcing companies pay more attention to the flexibility of packaging machines in pharmaceutical production. Reliability and operability. The integrated rigid foam liner packaging production line can well meet these needs and avoid cross contamination. Many production lines are dedicated to the production of specific drugs. However, under the pressure of reducing drug prices, drug manufacturers have to find ways to cut costs to maintain profits

however, it is not feasible to leave a large number of drug warehouses and production equipment idle for a long time, waiting for the production of the next batch of drugs. More and more production lines are used in the production of many different drugs, which leads to the problem of downtime in order to clean equipment and change production methods

according to the production schedule of the special production line, the time spent on changing the production line will basically not affect anything, because the next product will not start production immediately. Another factor is that the quantity of products required in each batch will gradually decline, because buyers will also adjust their strategies in time to reduce the consumption of raw materials to reduce costs. Different countries' markets will adopt different policies and regulations, which will affect the packaging specifications of drugs (that is, the number of drugs allowed in each package), how much market information can be printed on the package, where to print it, etc

many new paradigms have emerged. The most important point is that the fastest does not necessarily mean the highest production efficiency. For example, the current rigid foam liner packaging machine can pack 1200 products per minute, which can well meet the mass production process of half of the products. However, when the output of each batch of products is less than 1200, it is completely infeasible to try to save product production by changing the production speed of the packaging machine. When manufacturers choose packaging machines, they are more and more inclined to consider their own production scale and choose appropriate packaging machines: how many batches of products to produce in total, how large the scale of each batch of products, and ensuring the production time is the core issue, so equipment manufacturers have made continuous efforts to design better equipment; According to the provisions of the drug production management regulations (GMP) on the cleaning of drug production equipment, machines that are easy to clean are designed. In addition, these machines are also easy to change. Suitable for the production of a variety of products

due to the introduction of some measures

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